This is a surgical video demonstrating a forequarter amputation of the arm due to a high-grade angiosarcoma. The video presents the case of a 67-year-old man with severe left arm pain. The patient had a significant medical history of diabetes, hypertension, and previous kidney and lung transplants. Radiographs and MRIs demonstrated an expansile destructive lesion of the distal humerus with involvement of the musculature. Intraoperative biopsy was performed that demonstrated a high-grade epithelioid angiosarcoma. Angiosarcomas arising from bone are rare and highly malignant tumors. Owing to distal bone destruction of the upper extremity, a forequarter amputation was recommended to contain the metastases.