The anterolateral approach to the humerus allows access to the entire length of the humerus. The versatility of this allows for the intraoperative use of pre-contoured proximal or distal humerus plates, depending on the location and the extension of the fracture pattern. The radial nerve is directly visualized between the brachialis and brachioradialis and can be protected from devastating iatrogenic injury from poor implant placement. The literature shows a high rate of union and a low risk of iatrogenic radial nerve injury in patients who undergo open reduction and internal fixation of humeral shaft fractures via the anterolateral approach. The disadvantages of the anterolateral approach include a long visible scar over the anterolateral aspect of the brachium and more muscle dissection along the humerus.