Cervical disk herniation can result in focal compression of the spinal cord, giving rise to an ischemic lesion leading to myelopathy. Moreover, it can compress a nerve root, causing brachialgia and deficits of the upper limbs. Cervical radiculopathy and myelopathy are common in adults and their consequences may be as serious as spastic tetraplegia or nerve root paralysis. Anterior cervical diskectomy and fusion is one of the most commonly performed procedures, and it usually is associated with a good clinical outcome. It is mainly used if radiculopathy and/or myelopathy are the result of anterior compression and if one or two disk levels are involved. This video shows anterior cervical diskectomy and fusion in a 45-year-old man with C5-C6 disk herniation and myeloradiculopathy who had brachialgia, pectoral fasciculation, and weakness of the lower limbs associated with impaired ambulation. The surgical steps in this video include the anterolateral approach to the midcervical spine, diskectomy and decompression as described by Smith and Robinson, interbody fusion with the use of autologous bone graft harvested from the iliac crest, and stabilization with a plate and screws. Graphic illustrations are included in the video to better explain the technique. Anterior cervical diskectomy and fusion is a reliable procedure, leading to notable clinical and electrophysiologic improvement. This video may help surgeons at any stage of their career understand how to appropriately approach and manage cervical myeloradiculopathy. Potential pitfalls associated with this technique are reviewed and discussed.